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  Natural Healing for Bipolar Disorder

A Compendium of Nutritional Approaches
Some Investigational Targets

Copyright 2009  Eva Edelman

Disclaimer: These investigational targets should not to be construed as treatment directives.
This material is presented for educational purposes only

  Mania and Stabilization

Minerals: magnesium glycinate, zinc, trace-mineral-dose lithium orotate, etc., as relevant. May need to restrict copper and/or iron.
Inhibitory aminos: taurine (plus zinc), GABA (especially with histapenia or pyroluria), glycine (pyroluria). Perhaps, serotonin precursors.
B1, B3, B6, or other B vitamins, as relevant.
Vitamin C. Other antioxidants, as relevant.
Choline. Perhaps, omega 3 and/or GLA.
Kava (especially with histadelia), valerian (histapenia), theanine, skullcap, Bach Rescue Remedy, passion flower, as relevant.
Treat any thyroid overactivity; support blood sugar and adrenal balance; as relevant.
Treat histapenia, pyroluria, MT disorder, etc., as relevant.
Attend to Candida, allergies, toxicity, malabsorption, immune, neurological, and other health issues.
Decrease stressors (e.g., quiet, darkened room; regular meals, sleep, etc).
Increase support with seasonal change and other stressors.
IV therapies (e.g., C, B vitamins, magnesium), if indicated.


Inositol. Omega 3 and/or GLA. Perhaps, serine.
Tryptophan or tyrosine, if relevant. As relevant.
Support for cellular energetics: carnitine, NADH, CoQ10, perhaps creatine.
Vitamin D, morning sun.
B6, B12, folic, B5, B3, or other B vitamins, as relevant.
Vitamin C. Other antioxidants, as relevant.
Calcium/magnesium balance. Chromium. Sodium/potassium balance. Manganese, boron, cesium, rubidium, lithium, or germanium, if indicated. For some, mainly if deficient, copper or iron. Avoid vanadium.
St Johnswort (histadelia, pyroluria). Gotu kola, Siberian or American ginseng, ginkgo, noni, goji, acai, green tea.
Continue stabilizing aminos and minerals (zinc, magnesium, etc.), possibly, in some cases, at somewhat lower doses.
Treat any histadelia, pyroluria, etc., as relevant. Consider sulfur metabolism issues.
Thyroid, perhaps adrenal or other hormonal support, as indicated. Balance blood sugar.
Address: Candida, allergies, toxicity, malabsorption, immune, neurological, and other health issues.
Exercise, fresh air, nature. Optimal diet. Social interaction and support. Creative outlets.
Injection therapies, if needed, e.g., Myers (Gaby/Wright); B6, Mg, B1,B3, B5, B12, GSH, trace, etc. Contraindications are critical.

  Mixed State

EPA plus DHA. Inositol/choline balance.
Zinc. Magnesium/calcium balance. Potassium/sodium balance.
Inhibitory aminos. Theanine.
B1, B3, B6, C. Other relevant B vitamins and antioxidants.
Treat pyroluria, histadelia, histapenia, MT issues.
Correct: thyroid, adrenal, blood sugar, other hormonal imbalance.
Address allergies, Candida, toxicity, malabsorption, neurological, immune and other health issues, as relevant.
Reduce stress.

 Bipolar Psychosis

B3, B6, B1, zinc, magnesium.
C, E, selenium. Other relevant antioxidants.
Relevant EFAs.
Stabilizing aminos.
Treat histadelia or other biotypes, as relevant.
Address: allergies, Candida, blood sugar, seizural issues, metal accumulation, immune issues, thyroid or adrenal imbalances, and other health issues.

 Ongoing Mood Stability

Address biotype requirements.
Stabilizing minerals, aminos, B vitamins, antioxidants, EFAs, etc. as relevant to individual biochemistry. (See Mania, above.)
Look for any physical illness or toxicity influencing symptoms.


Most bipolars fit into one or more of these biotypes. If so, biotype becomes a critical consideration in determining nutrient choices.

Histadelia - (brain undermethylation, high folate) -- B6, C, glutathione, methyl-B12, SAMe or methionine, perhaps TMG. Calcium, magnesium, niacinamide, omega 3, inositol. Vitamin E, A, selenium, other antioxidants. Serotonin support. Perhaps kava. AVOID: folic acid, DMAE.

Pyroluria - Zinc, B6, manganese, magnesium, GLA. Vitamin C, selenium, antioxidants. Vitamin B3, B5, biotin, boron, glycine. Serotonin support. Inositol and/or choline. AVOID: toxins.

Histapenia - (brain overmethylation, low folate) -- B3, C, zinc, B6, folic acid, B12, B5, B complex, perhaps NAD. Magnesium, manganese, selenium, perhaps molybdenum. Omega 3, E, antioxidants. GABA, choline, valerian, eventually, NAC. AVOID: Copper, methionine, SAMe, phenylalanine, TMG, DMG, 5HTP.

  Limit Toxicity

Sugar, Junk food.
Recreational drugs, such as, tobacco, caffeine, alcohol, street drugs. Also, look at medication effects.
Exposure to pesticides, herbicides, organic solvents, or other environmental or industrial toxins.
Excitotoxicity, (e.g., from MSG or aspartame). Therapy may involve: Magnesium, zinc, theanine, resveratrol, taurine, GABA, antioxidants (C, E, selenium, CoQ10, lipoic acid, anthocyanidins, glutathione). Avoid MSG and aspartame.
Toxic metals. Excess copper in histapenia, is typically due to metal enzyme dysfunction. In bipolars, high copper is mainly associated with high estrogen in women. Check also, toxic metal accumulation (e.g., mercury, vanadium, lead, aluminum). Therapy may include: zinc, B6, C, E, selenium, glutathione, manganese, molybdenum, antioxidants; eventually, NAC.

  Health Considerations

Neurological: Subconvulsive limbic seizures. Receptors (EFAs and phospholipids). Synaptic activity. Mitochondrial issues.
Endocrine dysregulation or imbalance. Hypothalamus, pituitary, thyroid, adrenals, pineal, pancreas, sex hormones.
Allergies (wheat, dairy, environmental, etc.).
Digestive function, malabsorption, leaky gut, Candida.
Autoimmune: rheumatoid arthritis, autoimmune thyroid, diabetes II, MS, lupus, etc.
Liver, kidneys, immune issues, cardiovascular, organic brain disorders, etc.

Warning: Therapy must be tailored to individual biochemical requirements, including contraindications. If you need treatment for bipolar disorder, or any other medical condition, consult a knowledgable physician. In some cases, this will be an orthomolecular or other nutritionally-oriented physician. For further info, see:"Natural Healing for Bipolar Disorder," available from

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