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  Natural Healing for Bipolar Disorder

A Compendium of Nutritional Approaches
Some Investigational Targets

Copyright 2009  Eva Edelman

Disclaimer: These investigational targets should not to be construed as treatment directives.
This material is presented for educational purposes only

  Mania and Stabilization

Minerals: magnesium glycinate, zinc, trace-mineral-dose lithium orotate, etc., as relevant. May need to restrict copper and/or iron.
Inhibitory aminos: taurine (plus zinc), GABA (especially with histapenia or pyroluria), glycine (pyroluria). Perhaps, serotonin precursors.
B1, B3, B6, or other B vitamins, as relevant.
Vitamin C. Other antioxidants, as relevant.
Choline. Perhaps, omega 3 and/or GLA.
Kava (especially with histadelia), valerian (histapenia), theanine, skullcap, Bach Rescue Remedy, passion flower, as relevant.
Moderate thyroid overactivity; support blood sugar and adrenal balance; as relevant.
Treat histapenia, pyroluria, MT disorder, etc., as relevant.
Attend to Candida, allergies, toxicity, malabsorption, immune, neurological, and other health issues.
Decrease stressors (e.g., quiet, darkened room; regular meals, sleep, etc).
Increase support with seasonal change and other stressors.
IV therapies (e.g., C, B vitamins, magnesium), if indicated.

  Depression

Inositol. Omega 3 and/or GLA. Perhaps, serine.
Tryptophan or 5HTP. Tyrosine, or perhaps phenylalanine. As relevant.
Support for cellular energetics: carnitine, NADH, CoQ10, perhaps creatine.
Vitamin D, morning sun.
B6, B12, folic, B5, B3, or other B vitamins, as relevant.
Vitamin C. Other antioxidants, as relevant.
Calcium/magnesium balance. Chromium. Sodium/potassium balance. Manganese, boron, cesium, rubidium, lithium, or germanium, if indicated. For some, mainly if deficient, copper or iron. Avoid vanadium.
St Johnswort (histadelia, pyroluria). Gotu kola, Siberian or American ginseng, ginkgo, noni, goji, acai, green tea.
Continue stabilizing aminos and minerals (zinc, magnesium, etc.), possibly, in some cases, at somewhat lower doses.
Treat any histadelia, pyroluria, etc., as relevant.
Thyroid, perhaps adrenal or other hormonal support, as indicated. Balance blood sugar.
Address: Candida, allergies, toxicity, malabsorption, immune, neurological, and other health issues.
Exercise, fresh air, nature. Optimal diet. Social interaction and support. Creative outlets.
Injection therapies, if needed, e.g., Myers (Gaby/Wright); B6, Mg, B1,B3, B5, B12, GSH, trace, etc. Contraindications are critical.

  Mixed State

EPA plus DHA. Inositol/choline balance.
Zinc. Magnesium/calcium balance. Potassium/sodium balance.
Inhibitory aminos. Theanine.
B1, B3, B6, C. Other relevant B vitamins and antioxidants.
Treat pyroluria, histadelia, histapenia, MT issues.
Correct: thyroid, adrenal, blood sugar, other hormonal imbalance.
Address allergies, Candida, toxicity, malabsorption, neurological, immune and other health issues, as relevant.
Reduce stress.

 Bipolar Psychosis

B3, B6, B1, zinc, magnesium.
C, E, selenium. Other relevant antioxidants.
Relevant EFAs.
Stabilizing aminos.
Treat histapenia, MT disorder, other biotypes, as relevant.
Address: allergies, Candida, blood sugar, seizural issues, immune issues, thyroid or adrenal imbalances, and other health issues.

 Ongoing Mood Stability

Stabilizing minerals, aminos, B vitamins, etc. as relevant to individual biochemistry. (See Mania, above.)
Antioxidants (C, bioflavonoids, E, selenium, CoQ10. Melatonin, D. Glutathione (especially with histadelia), or NAC (histapenia). Resveratrol, etc.
Relevant EFAs.
Metallothionein support, if relevant. Anti-excitotoxic nutrients. Anti-homocysteine nutrients, if indicated.

  Biotypes:

Pyroluria - Zinc, B6, manganese, magnesium, GLA. Vitamin C, selenium, antioxidants. vitamin B3, B5, biotin, boron, glycine. Serotonin support. Inositol and/or choline. AVOID: toxins .
Histapenia - (brain overmethylation, low folate) -- B3, NAD, zinc, C, B6, folate, B12, B5, B complex. Magnesium, manganese, selenium, perhaps molybdenum. Omega 3, E, antioxidants. GABA, choline, valerian, eventually, NAC. AVOID: Copper, methionine, SAMe, phenylalanine, TMG, DMG, 5HTP.
Histadelia - ((brain undermethylation, high folate) -- B6, C, SAMe, methionine, TMG, glutathione, perhaps methyl-B12. Calcium, magnesium, zinc, niacinamide, omega 3. Vitamin E, A, selenium, other antioxidants, inositol, serotonin support, kava. AVOID: folic acid, manganese, DMAE.

  Limit Toxicity

Sugar, Junk food. Pesticides. Tobacco, caffeine. Alcohol, substance abuse. Side effects of prescription drugs. Organic Solvents. Herbicides, pesticides.
Excitotoxicity. Therapy may involve: Magnesium, zinc, theanine, resveratrol, taurine, GABA, antioxidants (C, E, selenium, CoQ10, lipoic acid, anthocyanidins, glutathione). Avoid MSG and aspartame.
Metal metabolism disorder High copper in histapenia, is typically due to metal enzyme dysfunction. Suspect also with toxic metal accumulation (mercury, vanadium, lead, aluminum, etc). Therapy may include: zinc, B6, C, E, selenium, glutathione, manganese, molybdenum, antioxidants; eventually, NAC.

  Health Considerations

Neurological: Subconvulsive limbic seizures. Receptors (EFAs and phospholipids). Mitochondrial issues. VMATs.
Endocrine dysregulation or imbalance. Hypothalamus, pituitary. Thyroid, adrenals. Sex hormones. Blood sugar.
Allergies (wheat, dairy, environmental, etc.)
Digestive function, absorption, Candida.
Autoimmune: rheumatoid arthritis, autoimmune thyroid, diabetes II, MS, lupus, etc.
Liver, kidneys, immune issues, cardiovascular, organic brain disorders, etc.

Warning: Therapy must be tailored to individual biochemical requirements, including contraindications. If you need treatment for bipolar disorder, or any other medical condition, consult a knowledgable physician. In some cases, this will be an orthomolecular or other nutritionally-oriented physician. For further info, see:"Natural Healing for Bipolar Disorder," available from boragebooks.com

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